The qualities of the microbiota of the skin and the healing of injuries

The qualities of the microbiota of the skin and the healing of injuries

The skin, in addition to being the largest organ of the human body, acts as the first line of physical and immune defense. This capacity is also a complex and dynamic ecosystem, inhabited by a multitude of organisms such as bacteria, fungi and viruses. Currently, a group of researchers from the National Institute of Allergy and Infectious Diseases in Bethesda has described the way in which the microbiota of the skin induces the response of the immune system to a wound, a fact that favors its healing.
The results of the team, led by Yasmine Belkaid, have shown a kind of dialogue between the bacteria Staphylococcus epidermidis, naturally occurring in human skin, and a specific type of immune cells, the CD8 + T lymphocytes. Specifically, the microbiota is able to attract and activate these cells by non-classical molecules of the set of proteins known as major histocompatibility complex class I. In addition, scientists studying the gene expression profile of these lymphocytes induced by microorganisms. The analysis revealed an increase in the levels of those genes involved in tissue regeneration processes.
For researchers, this finding indicates that lymphocytes, in addition to defending the organism against aggression, must also promote the healing process. Experiments performed in adult mice confirmed their hypothesis, since CD8 + T cells accumulated at the edge of a wound in the ear of rodents. There, the lymphocytes activated the proliferation of keratinocytes, keratin protein secreting cells that stimulate epithelial tissue growth. Consequently, the healing time was shorter.
Thus, the data obtained in this research suggest that the microbiota and pathogenic bacteria induce different mechanisms of activation of the immune system.
A better understanding of the role of microbes in the immunity processes that can contribute to the development of new methods of tissue regeneration in surgical procedures from dental implants Tijuana to a life or death operation. Currently, this is a fundamental challenge in medicine, since the strategies available to treat wounds caused by injuries, surgical interventions or diseases are not always effective. If in the future, the results obtained in this study are confirmed in humans, this could be a great advance in modern medicinedev